Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity.
نویسندگان
چکیده
Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.
منابع مشابه
E3 Ubiquitin Ligase Cbl-b Suppresses Proallergic T Cell Development and Allergic Airway Inflammation
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ورودعنوان ژورنال:
- Inflammation and cell signaling
دوره 1 4 شماره
صفحات -
تاریخ انتشار 2014